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Medication Detail

image of medication detailed on this page

Medication Type

Long Term Control, should be taken every day as prescribed

Generic Names

Fluticasone Furoate, Umeclidinium and Vilanterol

Brand Names

Trelegy Ellipta®


This medication is a combination inhaler used once daily to treat long term asthma symptoms. It prevents irritation and swelling in the airways, and causes muscles in the airways to relax over time, opening them for easier breathing.


DPI (dry powder inhaler)


Trelegy Ellipta cannot be used with a spacer


Adults 18 years of age and older: One inhalation once a day. Two strengths are available: 100/62.5/25 mcg per actuation and 200/62.5/25 mcg per actuation.

Proper Use

  • See instructions for proper use. Take this medication at the same time each day and not more than once in a 24 hour period.
  • Trelegy Ellipta comes in a foil tray. Peel back the lid and throw away the tray and drying packet that comes with the tray.
  • Write the date that you opened the tray on the inhaler label. The inhaler is good for 6 weeks only, so also write the "discard date" on the label (discard date is 6 weeks after you opened the tray).
  • Do not open the inhaler cover until you are ready to use. Each time you open the cover, a dose is prepared for use. When you are ready to use, open the cover. You should hear a "click" and the counter should go down by 1.
  • Do not shake the inhaler.
  • Breathe out fully and hold the inhaler like a hamburger with both hands. Bring the mouthpiece to your mouth and close your lips around the curved mouthpiece.
  • Breathe in deeply and slowly through your mouth. Do not block the air vent with your fingers.
  • Remove the mouthpiece and hold your breath for 3 or 4 seconds. Breathe out slowly and gently. Close the inhaler.
  • Rinse your mouth with water and spit out.


  • Do NOT use this drug to treat an asthma attack. Continue to use this medication as prescribed, even if asthma symptoms are not present.
  • You should not use this drug if you are allergic to fluticasone, umeclidinium, vilanterol or milk proteins.
  • Talk with your doctor before you stop using this drug. You may want to slowly stop this drug.
  • Talk with your doctor if you have heart disease, high blood pressure, seizures, a weak immune system, liver disease, vision problems, diabetes, osteoporosis, thyroid disorder, urination problems, if you are being treated for any type of infection, or if you have a severe milk allergy.

Common Interactions

  • Some of the medications Trelegy Ellipta interacts with include atropine; antifungal or antiviral medicines; cold or allergy medicine (such as Benedryl); medicines to treat Parkinson’s disease; medicines to treat stomach problems, overactive bladder, motion sickness or irritable bowel syndrome; other bronchodilator asthma medication.
  • Tell your doctor and pharmacist about all of your medications and health problems so they can check for any interactions.

Possible Side Effects

Tell your doctor or seek medical attention right away if you have signs of an allergic reaction (hives; difficult breathing; swelling of your face, lips, tongue or throat); tremors, nervousness, chest pain, fast or pounding hearbeats; fever chills, cough with mucus, feeling short of breath; sores or white patches in your mouth and throat, pain while swallowing; wheezing or other breathing problems after using this medicine; trouble with urination; trouble with vision; high blood sugar; low potassium level; signs of a hormonal disorder.

Common side effects may include: body aches or pain, cough, headache, hoarse voice, sneezing, sore throat, stuffy/runny nose, joint pain, bowel changes, nausea/vomiting, mouth pain/changes in your sense of taste.

Proper Storage

  • Store at room temperature.
  • Keep in a dry place away from heat and sunlight.
  • Store in the unopened tray and only open when ready for use.
  • When there are fewer than 10 doses remaining, the dose counter will show a "red" color as a reminder to get a refill. When the dose counter says 0 or the discard date has been reached (whichever happens first), throw the inhaler away.

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